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California-based biotech Gritstone have recently launched a Phase I clinical trial in Manchester, using a method known as self-amplifying RNA (saRNA), a newer form of the mRNA technology. Initially designed for use against cancer, saRNA produces copies of itself once inside the body's cells, meaning that you can induce the same response as an mRNA vaccine, but with a dose that is 50 or 100 times smaller, making the vaccine cheaper and easier to make.

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