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For Akston Biosciences and the other new challengers vying for a part of the market, the price of commercial failure is potentially very high. Two years ago Novavax saw a clinical trial for an RSV vaccine crash and burn. The process cost them tens of millions of dollars, resulted in employees being laid off, and the sell-off of two development and manufacturing facilities.

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To date an estimated 47.7% of the world's population, including large swathes of South America, Africa and Asia, is yet to receive even one coronavirus vaccine dose. The great hope for second generation vaccines is that they can make major inroads into this problem, especially as unvaccinated populations are at even greater risk from any new variants that might emerge.
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"We have been invited to Rwanda to see what we can do," says Conradson. "There's been a lot of initiatives in Africa at the moment. We've had so many contacts from the African CDC, African Development Bank, the African vaccine manufacturers, there's a whole bunch of initiatives."

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Even if some of the second generation vaccines never make it to market for Covid-19, the vast investments in research and accelerating manufacturing processes, may yet bring major health benefits in the realms of other diseases. Vaxart are also looking to create vaccine-based pills for flu and norovirus, while CureVac and GSK are aiming to produce a jab which vaccinates against coronaviruses and influenza at the same time.
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